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PrkdcTg(INS-PDE2)5-1Lmb
Transgenic Allele Detail
Summary
Symbol: PrkdcTg(INS-PDE2)5-1Lmb
Name: protein kinase, DNA activated, catalytic polypeptide; transgene insertion 5-1, Laboratory of Molecular Biology
MGI ID: MGI:3620758
Synonyms: PrkdcTgN(InsSRA5)slipLmb, slip, Sra5-1
Gene: Prkdc  Location: Chr16:15455730-15660099 bp, + strand  Genetic Position: Chr16, 10.09 cM, cytoband B1
Alliance: PrkdcTg(INS-PDE2)5-1Lmb page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Hypomorph)
Mutation:    Insertion
 
Mutation detailsA transgene containing an expression construct for yeast cAMP phosphodiesterase (SRA5) under the control of the human insulin promoter randomly inserted into the Prkdc gene, disrupting the normal function of this gene. Expression of Prkdc was shown to be abolished by RT-PCR analysis on RNA derived from homozygous spleen and thymus. Expression of the transgene was negligible. Complementation analysis with Prkdcscid mice confirmed that the insertion mutation is an allele of the Prkdc gene. (J:44390)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkdc Mutation:  417 strains or lines available
References
Original:  J:44390 Jhappan C, et al., DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat Genet. 1997 Dec;17(4):483-6
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory