Crl1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Crl1^DBA/2J
• Name: complement receptor lymphocyte 1; DBA/2J
• MGI ID: MGI:3620772
• QTL: Crl1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers lower rate of B-lymphocyte complement receptor appearance compared to AKR/J. (J:5442)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:5442

Authors use a series of H2 congenic strains, B10.BR, B10.D2, B10.A, A.CA, A.SW and A.BY and H2 recombinants B10.A(4R), B10.A(5R) and B10.A(2R), to locate Crl1 between H2-S and H2-T18 on mouse Chromosome 17. Crl1 is a locus influencing the rate of appearance of complement receptors on B lymphocytes, and was also mapped to the H2 locus in a (AKR/J x DBA/2J)F1 x DBA/2J backcross. Parental strain AKR/J exhibits a higher rate of complement receptor appearance on lymphocytes at 2 weeks of age compared to parental strain DBA/2J. The AKR/J-derived allele at Crl1 confers a high frequency of complement receptor lymphocytes, whereas homozygosity for DBA/2J-derived alleles at Crl1 confers low complement receptor levels at 2 weeks of age. Analysis of H2 recombinant haplotypes indicates that Crl1 is between the H2-S (18.8 cM; formerly Ss-Slp) and H2-T18 (19.78 cM; formerly H2-Tla) loci. Crl1 was confirmed in a congenic line carrying A/WySnJ-derived H2 locus on a C57BL/10J genetic background. Donor strain A/WySnJ exhibits an intermediate rate of complement receptor appearance whereas background strain C57BL/10J exhibits low frequency. The B10.A-H2 congenic exhibits an intermediate rate of complement receptor appearance similar to the donor strain. At least one other non-H2 linked gene influences the level of complement receptors at 2 weeks of age.

References

• Original: J:5442 Gelfand MC, et al., Ontogeny of B lymphocytes. 3. H-2 linkage of a gene controlling the rate of appearance of complement receptor lymphocytes. J Exp Med. 1974 May 1;139(5):1142-53
• All: 1 reference(s)