Tmevp3^C57BL/10SnSg
QTL Variant Detail

Summary

• QTL variant: Tmevp3^C57BL/10SnSg
• Name: Theiler's murine encephalomyelitis virus persistence 3; C57BL/10SnSg
• MGI ID: MGI:3620798
• QTL: Tmevp3 Location: Chr10:118389670-118490968 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: C57BL/10SnSg

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to infection by Theiler's virus compared to SJL/J. (J:54593)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:54593

Theiler's virus persistently infects the white matter of spinal cord in susceptible strains of mice. This infection is associated with inflammation and primary demyelination and is studied as a model of multiple sclerosis. The SJL/J strain is more susceptible than the B10.S strain. Screening of a (SJL/J x B10.S)F1 x B10.S backcross identified a locus in the telomeric region of Chromosome 10. Analysis of 14 congenic lines carrying different segments of Chromosome 10 identified the presence of two loci controlling viral persistence in the telomeric region of Chromosome 10. These loci have been designated as Tmevp2 and Tmevp3. Tmevp2 is located between D10Mit68 (51.5 cM) and D10Mit73 (62 cM) and Tmevp3 is between D10Mit74 (65 cM) and D10Mit234/D10Mit14 (65 cM). Futhermore, the susceptible allele of the Tmevp2 locus is dominant and the susceptible allele of the Tmevp3 locus is recessive. C57BL/10-derived alleles at Tmevp2 and Tmevp3 confer resistance to Theiler's virus. Moreover, males were more infected than females. Also Ifng was excluded as a candidate gene from the regions containing Tmevp2 and Tmevp3.

J:73275

The authors constructed a BAC contig around the Tmevp3 locus on Chromosome 10 by screening a CITB mouse BAC library. The order of markers was determined to be: centromere - Ifng - D10Mit74 - D10Mit234 - D10Mit14 - telomere. Using comparative sequence analysis with human genomic sequence from Chromosome 12 and homologies with expressed sequence tags, a locus termed Tmevpg1 was identified in a 173kb region around the mouse BAC 13C18. The locus appeared to produce a non-protein coding mRNA.

References

• Original: J:54593 Bihl F, et al., Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice. Genetics. 1999 May;152(1):385-92
• All: 1 reference(s)