Blm^tm1Khor
Targeted Allele Detail

Summary

• Symbol: Blm^tm1Khor
• Name: Bloom syndrome, RecQ like helicase; targeted mutation 1, Kyoji Horie
• MGI ID: MGI:3620977
• Synonyms: Blm^tet, Blm^tetN
• Gene: Blm Location: Chr7:80104839-80184896 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Blm^tm1Khor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106458
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A cassette containing a tetracycline-controlled transactivator (tTA), and a tetracycline responsive element (TRE) was inserted upstream of the translation start site in exon 2. Blm expression in mutants was present in the absence of dox. Upon administration of dox, expression was reduced, however, leaky expression was found in all tissues examined. (J:106458, J:107374)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Blm Mutation: 88 strains or lines available

References

• Original: J:106458 Hayakawa T, et al., Bloom's syndrome gene-deficient phenotype in mouse primary cells induced by a modified tetracycline-controlled trans-silencer. Gene. 2006 Mar 15;369:80-9
• All: 4 reference(s)