Sfrp1^tm1Aksh
Targeted Allele Detail

Summary

• Symbol: Sfrp1^tm1Aksh
• Name: secreted frizzled-related protein 1; targeted mutation 1, Akihiko Shimono
• MGI ID: MGI:3621116
• Synonyms: Sfrp1^-
• Gene: Sfrp1 Location: Chr8:23901518-23939648 bp, + strand Genetic Position: Chr8, 11.48 cM
• Alliance: Sfrp1^tm1Aksh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-T-lacZ-bpA cassette replaced the first exon, which encodes the functional domain of the protein. Beta-gal staining confirmed that expression reflected endogenous protein expression. Transcript was not detected in mutants. (J:106551)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sfrp1 Mutation: 19 strains or lines available

References

• Original: J:106551 Satoh W, et al., Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
• All: 25 reference(s)