Sfrp2^tm1Aksh
Targeted Allele Detail

Summary

• Symbol: Sfrp2^tm1Aksh
• Name: secreted frizzled-related protein 2; targeted mutation 1, Akihiko Shimono
• MGI ID: MGI:3621117
• Synonyms: Sfrp2^-
• Gene: Sfrp2 Location: Chr3:83673628-83681621 bp, + strand Genetic Position: Chr3, 37.37 cM
• Alliance: Sfrp2^tm1Aksh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1 of the locus, which encodes the functional domain of the protein, with a loxP-flanked PGK-neopbA. Transcript was not detected in mutants. (J:106551)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sfrp2 Mutation: 30 strains or lines available

References

• Original: J:106551 Satoh W, et al., Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
• All: 14 reference(s)