Hmga1^tm1Afus
Targeted Allele Detail

Summary

• Symbol: Hmga1^tm1Afus
• Name: high mobility group AT-hook 1; targeted mutation 1, Alfredo Fusco
• MGI ID: MGI:3621126
• Gene: Hmga1 Location: Chr17:27775471-27782648 bp, + strand Genetic Position: Chr17, 14.5 cM
• Alliance: Hmga1^tm1Afus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106702
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons III through V were replaced with a neomycin resistance cassette. RT-PCR failed to detect transcript from mutant hearts and spleens. (J:106702)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmga1 Mutation: 23 strains or lines available

Notes

NOTE: The original reference for this allele has been retracted. However, the retraction does not impact the description of the allele or the phenotype.

References

• Original: J:106702 Fedele M, et al., Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. (Retracted). Cancer Res. 2006 Mar 1;66(5):2536-43
• All: 3 reference(s)