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Maml1tm1Lizw
Targeted Allele Detail
Summary
Symbol: Maml1tm1Lizw
Name: mastermind like transcriptional coactivator 1; targeted mutation 1, Lizi Wu
MGI ID: MGI:3621180
Synonyms: Maml1-
Gene: Maml1  Location: Chr11:50146461-50183138 bp, - strand  Genetic Position: Chr11, 30.42 cM
Alliance: Maml1tm1Lizw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106711
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced the first exon and the 5' promoter region. Northern and Western blot confirmed the loss of transcript and protein expression, respectively. (J:106711)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Maml1 Mutation:  26 strains or lines available
References
Original:  J:106711 Shen H, et al., The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. Genes Dev. 2006 Mar 15;20(6):675-88
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory