Maml1^tm1Lizw
Targeted Allele Detail

Summary

• Symbol: Maml1^tm1Lizw
• Name: mastermind like transcriptional coactivator 1; targeted mutation 1, Lizi Wu
• MGI ID: MGI:3621180
• Synonyms: Maml1^-
• Gene: Maml1 Location: Chr11:50146461-50183138 bp, - strand Genetic Position: Chr11, 30.42 cM
• Alliance: Maml1^tm1Lizw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the first exon and the 5' promoter region. Northern and Western blot confirmed the loss of transcript and protein expression, respectively. (J:106711)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Maml1 Mutation: 26 strains or lines available

References

• Original: J:106711 Shen H, et al., The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. Genes Dev. 2006 Mar 15;20(6):675-88
• All: 2 reference(s)