Tg(MT2A-TGFBR2)#Rser
Transgene Detail
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Symbol: |
Tg(MT2A-TGFBR2)#Rser |
Name: |
transgene insertion, Rosa Serra |
MGI ID: |
MGI:3621366 |
Synonyms: |
DnTGFbetaRII, MT-DNIIR |
Transgene: |
Tg(MT2A-TGFBR2)#Rser Location: unknown
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Alliance: |
Tg(MT2A-TGFBR2)#Rser page
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Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(MT2A-TGFBR2)#Rser expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
TGFBR2 (7048) |
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Mutation details: The transgene contains a truncated human TGFBR2 gene under the control of the human MT2A promoter. The truncated receptor contains the extracellular, transmembrane, and juxtamembrane domains. Most of the cytoplasmic domain including the kinase domain is deleted. This mutant receptor acts as a dominant-negative mutation. The promoter contains four metal responsive elements and a beta-globin TATA element, splice sites, and polyadenylation signal. This record represents pooled data or data where the line number is not specified.
(J:44579)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:44579 Serra R, et al., Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol. 1997 Oct 20;139(2):541-52 |
All: |
4 reference(s) |
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