Tg(Tcra2C,Tcrb2C)1Dlo
Transgene Detail

Summary

• Symbol: Tg(Tcra2C,Tcrb2C)1Dlo
• Name: transgene insertion 1, Dennis Y Loh
• MGI ID: MGI:3621454
• Synonyms: 2C TCR, 2C TCR-Tg
• Transgene: Tg(Tcra2C,Tcrb2C)1Dlo Location: unknown
• Alliance: Tg(Tcra2C,Tcrb2C)1Dlo page

Transgene origin

• Strain of Origin: (C57L x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra2C,Tcrb2C)1Dlo expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The transgene constructs encode a T cell receptor (TCR) that recognizes the L^d class I major histocompatibility complex (MHC) antigen SIYRYYGL peptide in the context of the H2^b MHC class I molecule. Rearranged genomic cosmids containing the entire Tcra and Tcrb coding and promoter regions from the cytotoxic T cell clone 2C were isolated and coinjected into fertilized eggs. Transgenic H2^b mice have large numbers of T cells in the periphery that express the transgenic TCR. In the periphery of transgenic H2^d mice, T cells expressing the transgenic TCR are deleted. (J:107523, J:120081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:107523 Sha WC, et al., Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 1988 Sep 15;335(6187):271-4
• All: 94 reference(s)