Gnasas1^tm1Jop
Targeted Allele Detail

Summary

• Symbol: Gnasas1^tm1Jop
• Name: GNAS antisense RNA 1; targeted mutation 1, Jo Peters
• MGI ID: MGI:3621477
• Synonyms: deltaNAS-DMR, Nespas^tm1Jop
• Gene: Gnasas1 Location: Chr2:174123030-174137229 bp, - strand Genetic Position: Chr2, 97.89 cM
• Alliance: Gnasas1^tm1Jop page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106793
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to delete 1.6 kb of genomic sequence covering the promoter, exon 1 and 631 bp of intronic sequence, leaving the Gnas minimum promoter region intact. The vector included a tACE-Cre gene for excision of the cassette in the male germ line. RT-PCR failed to detect transcript in paternally inherited mutants. (J:106793)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnasas1 Mutation: 6 strains or lines available

References

• Original: J:106793 Williamson CM, et al., Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster. Nat Genet. 2006 Mar;38(3):350-5
• All: 4 reference(s)