Rad51b^tm1Kmic
Targeted Allele Detail

Summary

• Symbol: Rad51b^tm1Kmic
• Name: RAD51 paralog B; targeted mutation 1, Eric B Kmiec
• MGI ID: MGI:3621480
• Synonyms: muREC2/RAD51L1^-
• Gene: Rad51b Location: Chr12:79344056-79861464 bp, + strand Genetic Position: Chr12, 35.51 cM
• Alliance: Rad51b^tm1Kmic page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58601
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An IRES-beta geo expression cassette was inserted into exon 2. A fusion transcript is expressed from this allele that consists of the inserted sequences from the expression cassette. This transcript cannot express normal protein due to the inclusion of a stop codon, resulting in a shift of all three reading frames. (J:58601)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad51b Mutation: 25 strains or lines available

References

• Original: J:58601 Shu Z, et al., Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background. Mol Cell Biol. 1999 Dec;19(12):8686-93
• All: 1 reference(s)