Ppp1r15a^tm1.1Ajf
Targeted Allele Detail

Summary

• Symbol: Ppp1r15a^tm1.1Ajf
• Name: protein phosphatase 1, regulatory subunit 15A; targeted mutation 1.1, Albert J Fornace, Jr
• MGI ID: MGI:3621811
• Synonyms: Gadd34^-
• Gene: Ppp1r15a Location: Chr7:45172341-45175692 bp, - strand Genetic Position: Chr7, 29.34 cM, cytoband B2
• Alliance: Ppp1r15a^tm1.1Ajf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106905
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination was used to remove exons 2 and 3 from the locus. Northern blot of mutant intestine, kidney and spleen failed to detect transcript. (J:106905)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp1r15a Mutation: 23 strains or lines available

References

• Original: J:106905 Patterson AD, et al., Gadd34 requirement for normal hemoglobin synthesis. Mol Cell Biol. 2006 Mar;26(5):1644-53
• All: 9 reference(s)