Tnks2^tm1Susm
Targeted Allele Detail

Summary

• Symbol: Tnks2^tm1Susm
• Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; targeted mutation 1, Susan Smith
• MGI ID: MGI:3621819
• Synonyms: Tnks^PDdelta
• Gene: Tnks2 Location: Chr19:36811632-36870877 bp, + strand Genetic Position: Chr19, 31.96 cM
• Alliance: Tnks2^tm1Susm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106917
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 25-27, encoding the PARP domain, with a neomycin resistance cassette. The vector was designed using the exon nomenclature in J:71663. This allele was expected to produce a null, however, truncated proteins were expressed from the locus that lacked the catalyitic PARP domain. Smaller proteins putatively contain the ANK and SAM domains and larger proteins are probably variants splicing the truncated protein to the downstream neo. (J:106917)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnks2 Mutation: 48 strains or lines available

References

• Original: J:106917 Hsiao SJ, et al., Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol. 2006 Mar;26(6):2044-54
• All: 1 reference(s)