Lrp4^tm1Her
Targeted Allele Detail

Summary

• Symbol: Lrp4^tm1Her
• Name: low density lipoprotein receptor-related protein 4; targeted mutation 1, Joachim Herz
• MGI ID: MGI:3621893
• Synonyms: Lrp4ECD, Lrp4^hypo, Megf7^-
• Gene: Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Lrp4^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106811
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The locus was disrupted by the insertion of a stop codon just upstream of the transmembrane segment. Part of exon 36 and 2.1 kb of intron 36 were replaced with a neomycin resistance cassette. RT-PCR confirmed the complete lack of functional transcripts. (J:106811)

Expression

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp4 Mutation: 98 strains or lines available

References

• Original: J:106811 Johnson EB, et al., Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet. 2005 Nov 15;14(22):3523-38
• All: 8 reference(s)