Mchr1^tm1Yush
Targeted Allele Detail

Summary

• Symbol: Mchr1^tm1Yush
• Name: melanin-concentrating hormone receptor 1; targeted mutation 1, Yuguang Shi
• MGI ID: MGI:3621901
• Synonyms: Mchr1^-
• Gene: Mchr1 Location: Chr15:81119700-81123165 bp, + strand Genetic Position: Chr15, 38.02 cM
• Alliance: Mchr1^tm1Yush page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106819
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with a neomycin resistance cassette. Northern blot failed to detect transcript in mutants. (J:106819)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mchr1 Mutation: 25 strains or lines available

References

• Original: J:106819 Chen Y, et al., Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology. 2002 Jul;143(7):2469-77
• All: 3 reference(s)