Kcnab1^tm1Kwak
Targeted Allele Detail

Summary

• Symbol: Kcnab1^tm1Kwak
• Name: potassium voltage-gated channel, shaker-related subfamily, beta member 1; targeted mutation 1, Seung P Kwak
• MGI ID: MGI:3621902
• Synonyms: Kvbeta1^-
• Gene: Kcnab1 Location: Chr3:64856636-65285643 bp, + strand Genetic Position: Chr3, 30.15 cM
• Alliance: Kcnab1^tm1Kwak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106860
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1.1, which encodes the first 36 amino acids of the locus, was replaced by three copies of the HA epitope tag. A neomycin resistance cassette, flanked by loxP sites, was inserted into intron 1.1. (J:106860)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnab1 Mutation: 27 strains or lines available

References

• Original: J:106860 Aimond F, et al., Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes. Circ Res. 2005 Mar 4;96(4):451-8
• All: 1 reference(s)