Dkk3^tm1Cni
Targeted Allele Detail

Summary

• Symbol: Dkk3^tm1Cni
• Name: dickkopf WNT signaling pathway inhibitor 3; targeted mutation 1, Christof Niehrs
• MGI ID: MGI:3621929
• Synonyms: Dkk3^-
• Gene: Dkk3 Location: Chr7:111715224-111758264 bp, - strand Genetic Position: Chr7, 58.74 cM
• Alliance: Dkk3^tm1Cni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace most of exon 2 with an in-frame lacZ and floxed neo cassette. Immunohistochemistry demonstrated that expression in mutants was very weak and limited to the regions of the cerebral cortex. (J:106922)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dkk3 Mutation: 28 strains or lines available

References

• Original: J:106922 Barrantes Idel B, et al., Generation and characterization of dickkopf3 mutant mice. Mol Cell Biol. 2006 Mar;26(6):2317-26
• All: 13 reference(s)