Ctsf^tm1Hap
Targeted Allele Detail

Summary

• Symbol: Ctsf^tm1Hap
• Name: cathepsin F; targeted mutation 1, Harold A Chapman
• MGI ID: MGI:3621931
• Synonyms: Cat F^-
• Gene: Ctsf Location: Chr19:4905158-4910946 bp, + strand Genetic Position: Chr19, 4.12 cM
• Alliance: Ctsf^tm1Hap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106923
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistant gene replaced exons 7 through 9. Northern and Western analyses failed to detect transcript and protein, respectively. (J:106923)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsf Mutation: 20 strains or lines available

References

• Original: J:106923 Tang CH, et al., Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol. 2006 Mar;26(6):2309-16
• All: 1 reference(s)