Abcc2^tm1Ahs
Targeted Allele Detail

Summary

• Symbol: Abcc2^tm1Ahs
• Name: ATP-binding cassette, sub-family member 2; targeted mutation 1, Alfred H Schinkel
• MGI ID: MGI:3621934
• Synonyms: Mrp2^-, Mrp2⁰
• Gene: Abcc2 Location: Chr19:43770747-43826771 bp, + strand Genetic Position: Chr19, 36.67 cM
• Alliance: Abcc2^tm1Ahs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107822
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.7 kb fragment containing exons 4-6 was replaced with an inverted Pgk selection cassette. Complete absence of protein product was confirmed by Western blot analysis. (J:107822)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc2 Mutation: 90 strains or lines available

References

• Original: J:107822 Vlaming ML, et al., Carcinogen and anti-cancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice. J Pharmacol Exp Ther. 2006 Jul;318(1):319-27
• All: 8 reference(s)