Exz1^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Exz1^C57BL/6
• Name: adrenal X zone degeneration 1; C57BL/6
• MGI ID: MGI:3621948
• QTL: Exz1 Location: unknown Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:8718

The adrenal X-zone degenerates by 60 to 70 days of age in animals from inbred strain BALB/cBy while the adrenal X-zone of inbred strain C57BL/6By persists at this time point. The strain distribution pattern of adrenal X-zone degeneration in 7 CXB (C=BALB/c; B=C57BL/6) recombinant inbred (RI) strains mapped a locus named Exz1 (adrenal X zone degeneration 1) to mouse Chromosome 16. The Exz1 locus may be linked to Ly7 at 27.7 cM.

A second locus named Exz2 (adrenal X zone degeneration 2) is thought to reside on mouse Chromosome 12. The strain distribution pattern of Exz2 matches that of Serpina1 (previously named Pre-1) at 51 cM.

BALB/c-derived alleles at Exz1 and Exz2 appear to confer earlier X-zone degeneration with a dominant mode of inheritance.

References

• Original: J:8718 Janat MF, et al., The adrenal X-zone of mice: genetic analysis of its development with recombinant-inbred strains. Exp Biol. 1987;46(4):217-21
• All: 1 reference(s)