Sp4^tm2.1Krc
Targeted Allele Detail

Summary

• Symbol: Sp4^tm2.1Krc
• Name: trans-acting transcription factor 4; targeted mutation 2.1, Kenneth R Chien
• MGI ID: MGI:3621971
• Synonyms: HF-1b^-
• Gene: Sp4 Location: Chr12:118198668-118265175 bp, - strand Genetic Position: Chr12, 63.48 cM
• Alliance: Sp4^tm2.1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107057
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was removed via cre-mediated excision by crossing with Tg(Prm-cre)58Og mice. Semi-quantitative RT-PCR demonstrated a complete deletion of transcript in mutant heart samples. (J:107057)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp4 Mutation: 35 strains or lines available

References

• Original: J:107057 St Amand TR, et al., Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol. 2006 Mar 15;291(2):208-17
• All: 1 reference(s)