Lxn^tm1Yari
Targeted Allele Detail

Summary

• Symbol: Lxn^tm1Yari
• Name: latexin; targeted mutation 1, Yasuyoshi Arimatsu
• MGI ID: MGI:3622076
• Synonyms: Lxn^-
• Gene: Lxn Location: Chr3:67365332-67371240 bp, - strand Genetic Position: Chr3, 30.98 cM
• Alliance: Lxn^tm1Yari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106948
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the coding sequence in exon 1. Western blot and immunohistochemistry failed to detect protein in mutant brain samples. (J:106948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lxn Mutation: 8 strains or lines available

References

• Original: J:106948 Jin M, et al., Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases. Brain Res. 2006 Feb 23;1075(1):117-21
• All: 3 reference(s)