Cacna2d1^tm1Cptl
Targeted Allele Detail

Summary

• Symbol: Cacna2d1^tm1Cptl
• Name: calcium channel, voltage-dependent, alpha2/delta subunit 1; targeted mutation 1, Charles P Taylor
• MGI ID: MGI:3622078
• Gene: Cacna2d1 Location: Chr5:16139786-16579502 bp, + strand Genetic Position: Chr5, 6.56 cM
• Alliance: Cacna2d1^tm1Cptl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106950
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: An R217A mutation was introduced into exon 8. Specific pregabalin binding in neocortex, hippocampus, basolateral amygdale and spinal cord was reduced. (J:106950)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna2d1 Mutation: 79 strains or lines available

References

• Original: J:106950 Bian F, et al., Calcium channel alpha(2)-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: An ex vivo autoradiographic study in alpha(2)-delta type 1 genetically modified mice. Brain Res. 2006 Feb 23;1075(1):68-80
• All: 2 reference(s)