Nod2^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Nod2^tm1Vmd
• Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:3622092
• Synonyms: Nod2^-
• Gene: Nod2 Location: Chr8:89373943-89415102 bp, + strand Genetic Position: Chr8, 43.51 cM, cytoband C3
• Alliance: Nod2^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106976
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a PGK-neomycin resistance cassette. Stop codons in all 3 reading frames were introduced after the exon 3 splice acceptor site. Western blot failed to detect protein in mutants. (J:106976)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nod2 Mutation: 63 strains or lines available

References

• Original: J:106976 Mariathasan S, et al., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006 Mar 9;440(7081):228-32
• All: 2 reference(s)