Dicer1^tm1Tara
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1Tara
• Name: dicer 1, ribonuclease type III; targeted mutation 1, Alexander Tarakhovsky
• MGI ID: MGI:3622169
• Synonyms: Dicer^f, Dicer^fl, Dicer^flox
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106792
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 22, which encodes the majority of the RNase III domain. Loss of this exon would result in the generation of in-frame stop codons generated by frameshift mutations, likely to destabilize the resulting transcript. Flp mediated recombination removed an FRT-flanked neo that was included in the vector. (J:106792)

Disease models

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dicer1^tm1Tara

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:106792 Yi R, et al., Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006 Mar;38(3):356-62
• All: 32 reference(s)