Hnf4a^tm1.1Mwei
Targeted Allele Detail

Summary

• Symbol: Hnf4a^tm1.1Mwei
• Name: hepatic nuclear factor 4, alpha; targeted mutation 1.1, Mary C Weiss
• MGI ID: MGI:3622273
• Synonyms: alpha1-only
• Gene: Hnf4a Location: Chr2:163348731-163414827 bp, + strand Genetic Position: Chr2, 84.32 cM
• Alliance: Hnf4a^tm1.1Mwei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106993
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutation: Disruption caused by insertion of vector
• Mutation details: The alpha7 specific exon 1D coding sequence was replaced by that of the alpha1 specific exon 1A such that only the alpha1 isoform was expressed. A floxed neo was deleted by mating with pgk-cre mice. RT-PCR confirmed recombination of locus. (J:106993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnf4a Mutation: 28 strains or lines available

References

• Original: J:106993 Briancon N, et al., In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J. 2006 Mar 22;25(6):1253-62
• All: 2 reference(s)