Tg(Myh6-Tmod1)65Msus
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tmod1)65Msus
• Name: transgene insertion 65, Mark A Sussman
• MGI ID: MGI:3622294
• Synonyms: Tg(alphaMHC-Tmod1), TOT
• Transgene: Tg(Myh6-Tmod1)65Msus Location: unknown
• Alliance: Tg(Myh6-Tmod1)65Msus page

HSPB7 represses formation of abnormal actin bundles independent of Tmod1

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tmod1)65Msus expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tmod1 (MGI:98775)

• Mutation details: The mouse alpha-MHC promoter drives the expression of full length mouse Tmod1. Three different founder lines were made, with these mice derived from line 65. Tmod1 expression is elevated over 3-fold at birth and shows a trend toward increasing expression up to almost 6-fold over the next 2.5 weeks. (J:58879, J:107823)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107823 Sussman MA, et al., Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. J Clin Invest. 1998 Jan 1;101(1):51-61
• All: 17 reference(s)