Hells^tm1Rarc
Targeted Allele Detail

Summary

• Symbol: Hells^tm1Rarc
• Name: helicase, lymphoid specific; targeted mutation 1, Robert J Arceci
• MGI ID: MGI:3622321
• Synonyms: Pasg^-
• Gene: Hells Location: Chr19:38919359-38959495 bp, + strand Genetic Position: Chr19, 33.57 cM, cytoband C3-D1
• Alliance: Hells^tm1Rarc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107145
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10-12, which encode the conserved helicase domains II through IV, were replaced with a neomycin resistance gene. A short transcript was detected by Northern blot, but Western blot detected no protein resulting from that transcript. (J:107145)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hells Mutation: 58 strains or lines available

References

• Original: J:107145 Sun LQ, et al., Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev. 2004 May 1;18(9):1035-46
• All: 1 reference(s)