Ripk2^tm2Cfl
Targeted Allele Detail

Summary

• Symbol: Ripk2^tm2Cfl
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 2, Chafen Lu
• MGI ID: MGI:3622329
• Gene: Ripk2 Location: Chr4:16122733-16163647 bp, - strand Genetic Position: Chr4, 6.7 cM
• Alliance: Ripk2^tm2Cfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107130
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed such that lysine 47 was mutated to an alanine (K47A), resulting in a kinase-dead protein. Transcript was produced, however, protein was significantly decreased in mutants. (J:107130)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk2 Mutation: 35 strains or lines available

References

• Original: J:107130 Lu C, et al., Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity. J Biol Chem. 2005 Apr 22;280(16):16278-83
• All: 2 reference(s)