In(7)4Rl
Radiation induced Allele Detail

Summary

• Symbol: In(7)4Rl
• Name: inversion, Chr 7, Russell 4
• MGI ID: MGI:3622350
• Synonyms: In(7)p^2DFiOD4Rl, In(7)p4Rl, In(7)p^4Rl, p^2DFiOD
• Gene: In(7)4Rl Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Strain of Origin: (101/Rl x C3H/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Inversion
• In(7)4Rl involves 269 genes/genome features (Gm10172, 6030442E23Rik, Gm29295 ...) View all
• Mutation details: This chromosomal inversion was discovered at Oak Ridge National Laboratory in descendants of pink-eyed progeny from a cross of an X-ray irradiated male mouse and a T-stock female homozygous for pink-eyed dilution (p). The chromosomal breakpoints were cytologically localized to bands 7C and 7E1. DNA analysis using probes for 13 genes between Ldhc and Igf1r, inclusive, found none of them to be deleted. Complementation by this inversion of all other lethal p alleles against which it was tested suggests the lethal phenotype is associated with the distal breakpoint, in the vicinity of the tyrosinase (Tyr) locus. This is borne out by its failure to complement the embryonic lethal Tyr-locus deletion Tyr^c-26DVT. (J:29903, J:29904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any In(7)4Rl Mutation: 0 strains or lines available

References

• Original: J:29903 Russell LB, et al., Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Genetics. 1995 Dec;141(4):1547-62
• All: 2 reference(s)