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In(7)4Rl
Radiation induced Allele Detail
Summary
Symbol: In(7)4Rl
Name: inversion, Chr 7, Russell 4
MGI ID: MGI:3622350
Synonyms: In(7)p2DFiOD4Rl, In(7)p4Rl, In(7)p4Rl, p2DFiOD
Gene: In(7)4Rl  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Strain of Origin:  (101/Rl x C3H/Rl)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Inversion
  In(7)4Rl involves 269 genes/genome features (Gm10172, 6030442E23Rik, Gm29295 ...) View all
 
Mutation detailsThis chromosomal inversion was discovered at Oak Ridge National Laboratory in descendants of pink-eyed progeny from a cross of an X-ray irradiated male mouse and a T-stock female homozygous for pink-eyed dilution (p). The chromosomal breakpoints were cytologically localized to bands 7C and 7E1. DNA analysis using probes for 13 genes between Ldhc and Igf1r, inclusive, found none of them to be deleted. Complementation by this inversion of all other lethal p alleles against which it was tested suggests the lethal phenotype is associated with the distal breakpoint, in the vicinity of the tyrosinase (Tyr) locus. This is borne out by its failure to complement the embryonic lethal Tyr-locus deletion Tyrc-26DVT. (J:29903, J:29904)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any In(7)4Rl Mutation:  0 strains or lines available
References
Original:  J:29903 Russell LB, et al., Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Genetics. 1995 Dec;141(4):1547-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory