Braf^tm1.1Sva
Targeted Allele Detail

Summary

• Symbol: Braf^tm1.1Sva
• Name: Braf transforming gene; targeted mutation 1.1, Alcino Silva
• MGI ID: MGI:3622462
• Synonyms: B-raf^-, B-raf^delta, B-raf^exon12-, Braf^exon9, Mox2^cre;B-raf^delta
• Gene: Braf Location: Chr6:39580171-39702397 bp, - strand Genetic Position: Chr6, 18.43 cM
• Alliance: Braf^tm1.1Sva page

Embryonic development abnormalities in Braf^tm1.1Sva/Braf^tm1.1Sva mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105998
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed sequence containing the first exon to encode the kinase domain (exon 12; exon 9 according to nomenclature in J:29234) was removed via cre mediated recombination. (J:105998)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Braf Mutation: 60 strains or lines available

References

• Original: J:105998 Galabova-Kovacs G, et al., Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
• All: 2 reference(s)