Tg(Fabp4-Hsd11b1)7Jesf
Transgene Detail

Summary

• Symbol: Tg(Fabp4-Hsd11b1)7Jesf
• Name: transgene insertion 7, Jeffrey S Flier
• MGI ID: MGI:3622478
• Synonyms: aP2-HSD1
• Transgene: Tg(Fabp4-Hsd11b1)7Jesf Location: unknown
• Alliance: Tg(Fabp4-Hsd11b1)7Jesf page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-Hsd11b1)7Jesf expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Hsd11b1 (25116)

  Hsd11b1

  (MGI:103562)

• Mutation details: This transgene consists of the rat Hsd11b1 gene under the control of the enhancer-promoter region of the adipocyte fatty acid binding protein (Fabp4) gene. Hsd11b1 transcript is expressed equivalently in adipose tissue from subcutaneous, abdominal, epididymal, mesenteric, and interscapular brown adipose tissue depots but is absent in brain, liver, skeletal muscle and kidney. Hsd11b1 mRNA is increased 7-fold compared to endogenous mRNA and activity is increased 2.4-fold in subcutaneous abdominal fat and 2.7-fold in epididymal fat. (J:107046)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107046 Masuzaki H, et al., A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001 Dec 7;294(5549):2166-70
• All: 2 reference(s)