Tg(INS-Il10)#Sar
Transgene Detail

Summary

• Symbol: Tg(INS-Il10)#Sar
• Name: transgene insertion #, Nora Sarvetnick
• MGI ID: MGI:3622661
• Transgene: Tg(INS-Il10)#Sar Location: unknown
• Alliance: Tg(INS-Il10)#Sar page

Tg(INS-Il10)#Sar/0 mice accumulate imflammatory cells within exocrine pancreatic tissue

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(INS-Il10)#Sar expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il10 (MGI:96537)

• Mutation details: A 594-bp fragment encoding the murine Il10 was inserted behind the human insulin promoter which is in a vector also containing the termination sequence from the hepatitis B virus gene. Il10 is expressed by the islet of Langerhans cells in the pancreas. (J:107927)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107927 Wogensen L, et al., Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans. J Exp Med. 1993 Jul 1;178(1):175-85
• All: 5 reference(s)