Tcea1^tm1Skmz
Targeted Allele Detail

Summary

• Symbol: Tcea1^tm1Skmz
• Name: transcription elongation factor A (SII) 1; targeted mutation 1, Kazuhisa Sekimizu
• MGI ID: MGI:3622786
• Synonyms: S-II^-
• Gene: Tcea1 Location: Chr1:4928037-4968132 bp, + strand Genetic Position: Chr1, 1.79 cM
• Alliance: Tcea1^tm1Skmz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107421
• Parent Cell Line: E14TG2aIV (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced most of the fourth exon that encodes amino acids 78-106. Absence of protein at E13.5 was confirmed by Western blot analysis. (J:107421)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcea1 Mutation: 66 strains or lines available

References

• Original: J:107421 Ito T, et al., Transcription elongation factor S-II is required for definitive hematopoiesis. Mol Cell Biol. 2006 Apr;26(8):3194-203
• All: 2 reference(s)