Hcn2^tm2Ldw
Targeted Allele Detail

Summary

• Symbol: Hcn2^tm2Ldw
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2; targeted mutation 2, Andreas Ludwig
• MGI ID: MGI:3623002
• Synonyms: HCN2^L2
• Gene: Hcn2 Location: Chr10:79552468-79571942 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Hcn2^tm2Ldw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81398
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette and a single loxP site flanking exons 2 and 3 were introduced via homologous recombination. The floxed neo cassette was removed by transient expression of cre recombinase in correctly targeted cells leaving exons 2 and 3 flanked by loxP sites. (J:81398)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn2 Mutation: 31 strains or lines available

References

• Original: J:81398 Ludwig A, et al., Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 2003 Jan 15;22(2):216-24
• All: 2 reference(s)