Ts(16C-tel)1Cje
Spontaneous Allele Detail

Summary

• Symbol: Ts(16C-tel)1Cje
• Name: trisomy, (16C-tel), 1 Charles J Epstein
• MGI ID: MGI:3623022
• Synonyms: partial trisomy 16, Ts108Cje, Ts(12¹⁶)1Cje, Ts1Cje
• Gene: Ts(16C-tel)1Cje Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47907
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Translocation
• Ts(16C-tel)1Cje involves 242 genes/genome features (Dnah11, Gm49602, Sp4 ...) View all
• Mutation details: This chromosomal trisomy comprises two normal Chr 16s and the reciprocal translocation product 12¹⁶. Mice are trisomic for the cytogenetic interval 16C-tel and the genetic interval Sod1 to Mx1. Sod1 is not functionally trisomic because the Sod1 gene in the translocated segment is inactivated by the insertion of the neomycin resistance sequence. The Ts1Cje mouse model of Down syndrome is trisomic for 94 genes on Mmu16, covering approximately two-thirds of the trisomic region in Ts65Dn mice. (J:47907, J:160790, J:178872)

Disease models

Expression

In Mice Carrying this Mutation:	56 assay results 9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ts(16C-tel)1Cje Mutation: 1 strain or line available

References

• Original: J:47907 Sago H, et al., Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6256-61
• All: 60 reference(s)