Afdn^tm1Ytk
Targeted Allele Detail

Summary

• Symbol: Afdn^tm1Ytk
• Name: afadin, adherens junction formation factor; targeted mutation 1, Yoshimi Takai
• MGI ID: MGI:3623108
• Synonyms: afadin^-
• Gene: Afdn Location: Chr17:13980735-14126059 bp, + strand Genetic Position: Chr17, 8.95 cM, cytoband A2
• Alliance: Afdn^tm1Ytk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57589
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance gene replaced exon 2. (J:57589)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Afdn Mutation: 84 strains or lines available

References

• Original: J:57589 Ikeda W, et al., Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J Cell Biol. 1999 Sep 6;146(5):1117-32
• All: 1 reference(s)