Ednrb^tm1(tTA)Tilg
Targeted Allele Detail

Summary

• Symbol: Ednrb^tm1(tTA)Tilg
• Name: endothelin receptor type B; targeted mutation 1, Shirley M Tilghman
• MGI ID: MGI:3623110
• Synonyms: Ednrb^tTA
• Gene: Ednrb Location: Chr14:104052055-104081764 bp, - strand Genetic Position: Chr14, 53.05 cM
• Alliance: Ednrb^tm1(tTA)Tilg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58698
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: The majority of the first exon and 230 base pairs of the first intron were replaced with the tTA coding region. The first exon encodes the amino-terminal extracellular domain and the first transmembrane domain of the locus. A neo flanked by two loxP sites was placed downstream of the tTA cassette, putting the transactivator protein under the control of the endogenous promoter. Crossing with mice expressing cre recombinase in the germline removed the floxed neo. (J:58698)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ednrb Mutation: 104 strains or lines available

References

• Original: J:58698 Shin MK, et al., The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature. 1999 Dec 2;402(6761):496-501
• All: 1 reference(s)