Gcgr^{tm1(GCGR)Kasu}
Targeted Allele Detail

Summary

• Symbol: Gcgr^{tm1(GCGR)Kasu}
• Name: glucagon receptor; targeted mutation 1, Kathleen A Sullivan
• MGI ID: MGI:3623116
• Synonyms: hGCGR
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^{tm1(GCGR)Kasu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58436
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The coding sequence was replaced with the coding sequence of human glucagons receptor such that expression is regulated by the endogenous 5' regulatory elements. RNase protection assay confirmed recombination in mutant mice. (J:58436)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 8 strains or lines available

References

• Original: J:58436 Shiao LL, et al., Generation of mice expressing the human glucagon receptor with a direct replacement vector. Transgenic Res. 1999 Aug;8(4):295-302
• All: 3 reference(s)