Hcls1^tm2Wtn
Targeted Allele Detail

Summary

• Symbol: Hcls1^tm2Wtn
• Name: hematopoietic cell specific Lyn substrate 1; targeted mutation 2, Takeshi Watanabe
• MGI ID: MGI:3623118
• Synonyms: HS1^3'ko
• Gene: Hcls1 Location: Chr16:36755345-36783574 bp, + strand Genetic Position: Chr16, 26.3 cM, cytoband B
• Alliance: Hcls1^tm2Wtn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28146
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exon 10 was disrupted by the insertion of a lacZ-neo cassette. A truncated protein comprised of residues 1-237 could potentially be produced, but would lack the acidic and amphipathic alpha-helix structure and the SH3 region. Protein was not detected in mutants. (J:28146)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcls1 Mutation: 29 strains or lines available

References

• Original: J:28146 Taniuchi I, et al., Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 1995 Aug 1;14(15):3664-78
• All: 2 reference(s)