Rag2^tm2Fwa
Targeted Allele Detail

Summary

• Symbol: Rag2^tm2Fwa
• Name: recombination activating gene 2; targeted mutation 2, Frederick W Alt
• MGI ID: MGI:3623131
• Synonyms: Rag2^GFP
• Gene: Rag2 Location: Chr2:101455063-101462874 bp, + strand Genetic Position: Chr2, 53.87 cM
• Alliance: Rag2^tm2Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57268
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A functional Rag2-GFP fusion cDNA replaced the endogenous coding sequence. A floxed neo was included in the vector and later removed via cre-mediated recombination. (J:57268)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag2 Mutation: 119 strains or lines available

References

• Original: J:57268 Monroe RJ, et al., RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 1999 Aug;11(2):201-12
• All: 5 reference(s)