Cln3^tm1Mkat
Targeted Allele Detail

Summary

• Symbol: Cln3^tm1Mkat
• Name: CLN3 lysosomal/endosomal transmembrane protein, battenin; targeted mutation 1, Martin L Katz
• MGI ID: MGI:3623134
• Gene: Cln3 Location: Chr7:126170571-126184991 bp, - strand Genetic Position: Chr7, 69.16 cM
• Alliance: Cln3^tm1Mkat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57155
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced most of exon 7 and all of exon 8. No complete transcript was detected in mutants, however, two smaller mRNA transcripts putatively resulting from alternative splicing around the neo were detected. (J:57155)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cln3 Mutation: 38 strains or lines available

References

• Original: J:57155 Katz ML, et al., A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease). J Neurosci Res. 1999 Aug 15;57(4):551-6
• All: 2 reference(s)