Arl3^{Gt(OST263303)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Arl3^{Gt(OST263303)Lex}
• Name: ADP-ribosylation factor-like 3; gene trap OST263303, Lexicon Genetics
• MGI ID: MGI:3623141
• Synonyms: Arl3^Gt(neo)1Lex
• Gene: Arl3 Location: Chr19:46519548-46561621 bp, - strand Genetic Position: Chr19, 38.94 cM, cytoband D1
• Alliance: Arl3^{Gt(OST263303)Lex} page

Mutation origin

• Mutant Cell Line: OST263303
• Germline Transmission: Earliest citation of germline transmission: J:107331
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a splice acceptor and neo was inserted into intron 1, downstream of the initiation codon. Absence of transcript was confirmed in mutant spleen and kidney. (J:107331)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST263303	CG598564 ; (MGI Seq Detail)	3' RACE	Chr19:46519800-46546821 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  62 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arl3 Mutation: 27 strains or lines available

References

• Original: J:107331 Schrick JJ, et al., ADP-ribosylation factor-like 3 is involved in kidney and photoreceptor development. Am J Pathol. 2006 Apr;168(4):1288-98
• All: 2 reference(s)