Ppard^tm1Dsvg
Targeted Allele Detail

Summary

• Symbol: Ppard^tm1Dsvg
• Name: peroxisome proliferator activator receptor delta; targeted mutation 1, Beatrice Desvergne
• MGI ID: MGI:3623147
• Synonyms: PPARbeta^-
• Gene: Ppard Location: Chr17:28451715-28520446 bp, + strand Genetic Position: Chr17, 14.64 cM
• Alliance: Ppard^tm1Dsvg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107381
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 4 and most of 5 with a PGK-neo cassette. The deleted sequence encodes the DNA-binding domain. Western blot confirmed absence of protein in mutant nuclear extracts. (J:107381)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppard Mutation: 68 strains or lines available

References

• Original: J:107381 Nadra K, et al., Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol. 2006 Apr;26(8):3266-81
• All: 22 reference(s)