Isl1^tm1(cre)Sev
Targeted Allele Detail

Summary

• Symbol: Isl1^tm1(cre)Sev
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Sylvia Evans
• MGI ID: MGI:3623159
• Synonyms: Isl1:Cre, Isl1^Cre, Isl1Cre
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm1(cre)Sev page

Hindlimb fusion of Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107396
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Isl1^tm1(cre)Sev expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Isl1 (MGI:101791)

• Mutation details: A cre gene and frt-flanked neo cassette were inserted 6 bp upstream of the translation initiation codon. The neo cassette was removed by germ line, flp-mediated recombination. Expression of cre is regulated by the endogenous promoter. (J:107396)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Isl1 (mouse) Summary of all recombinase alleles driven by Isl1. Comparative matrix view of recombinase activities Alliance mouse Isl1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

127 assay results 5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 36 strains or lines available

References

• Original: J:107396 Yang L, et al., Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr;133(8):1575-85
• All: 105 reference(s)