Disc1^del
Spontaneous Allele Detail

Summary

• Symbol: Disc1^del
• Name: disrupted in schizophrenia 1; deletion
• MGI ID: MGI:3623217
• Synonyms: Disc1^129S6, Disc1^delta6
• Gene: Disc1 Location: Chr8:125780934-125988597 bp, + strand Genetic Position: Chr8, 73.26 cM
• Alliance: Disc1^del page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: A 25 bp deletion in exon 6 causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon in exon 7. (J:107244)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 19 strains available Cell Lines: 0 lines available
• Carrying any Disc1 Mutation: 69 strains or lines available

Notes

This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T⁺ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).

References

• Original: J:107244 Koike H, et al., Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3693-7
• All: 15 reference(s)