Kmt2b^tm1.1Afst
Targeted Allele Detail

Summary

• Symbol: Kmt2b^tm1.1Afst
• Name: lysine (K)-specific methyltransferase 2B; targeted mutation 1.1, A Francis Stewart
• MGI ID: MGI:3623310
• Synonyms: Mll2 F, Mll2FC
• Gene: Kmt2b Location: Chr7:30268283-30288151 bp, - strand Genetic Position: Chr7, 18.63 cM, cytoband A3
• Alliance: Kmt2b^tm1.1Afst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107403
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked sA-IRES lacZ-neo pA cassette was removed from intron 1 of Mll2^tm1Afst via flp recombination and wild-type function was restored. (J:107403)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2b Mutation: 65 strains or lines available

References

• Original: J:107403 Glaser S, et al., Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development. 2006 Apr;133(8):1423-32
• All: 11 reference(s)