Kmt2b^tm1.2Afst
Targeted Allele Detail

Summary

• Symbol: Kmt2b^tm1.2Afst
• Name: lysine (K)-specific methyltransferase 2B; targeted mutation 1.2, A Francis Stewart
• MGI ID: MGI:3623312
• Synonyms: Mll2 FC
• Gene: Kmt2b Location: Chr7:30268283-30288151 bp, - strand Genetic Position: Chr7, 18.63 cM, cytoband A3
• Alliance: Kmt2b^tm1.2Afst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107403
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exon 2 was removed by cre recombination causing a frameshift in the transcript. (J:107403)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kmt2b Mutation: 65 strains or lines available

References

• Original: J:107403 Glaser S, et al., Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development. 2006 Apr;133(8):1423-32
• All: 2 reference(s)