Gabra5^tm1Twr
Targeted Allele Detail

Summary

• Symbol: Gabra5^tm1Twr
• Name: gamma-aminobutyric acid type A receptor subunit alpha 5; targeted mutation 1, Thomas W Rosahl
• MGI ID: MGI:3623342
• Synonyms: alpha5^-
• Gene: Gabra5 Location: Chr7:57057420-57159807 bp, - strand Genetic Position: Chr7, 33.52 cM
• Alliance: Gabra5^tm1Twr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108206
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 3 with a neomycin resistance gene. Western blot analysis failed to detect protein in mutant hippocampus. (J:108206)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra5 Mutation: 33 strains or lines available

References

• Original: J:108206 Collinson N, et al., Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor. J Neurosci. 2002 Jul 1;22(13):5572-80
• All: 16 reference(s)